Ensure you run stock DDR4 RAM speeds that is 2133mhz with stock timings. As you might be aware of Ryzen is a bit funky when it comes to RAM but higher MHz will yield a faster system. The RAM clock speeds tie into the infinity fabric that "glue's" chiplets together in the die. For the best results ensure you have Samsung B-Die or Hynix A-Die IC's, you can check the QVL or RAM manufacturer as well as use Typhoon Burner. Note the screenshot below has my D.O.C.P. profile the highest settings, keep the stock timings for now and change this after finishing your CPU overclock.
Now to get down to getting the best out of your chip without burning the house down. As always you are bound by the "silicon lottery" and on this draw, I have the short straw because I am not getting better clock speeds. Good chips can run 4.1Ghz with proper voltages mine are a bit on the high side and I tuned down my overclock just to be saved.